Regulatory reliance allows national regulatory authorities (NRAs) to draw on the scientific assessments and decisions of trusted, more experienced regulators while preserving their sovereign decision-making authority. This approach streamlines approvals, optimizes resources, and expands timely patient access to medicines and medical devices. Reliance also complements harmonization efforts, strengthens regulatory systems, and builds trust among stakeholders. This article provides an overview of reliance principles, highlights global and regional initiatives, and explores their implications for regulatory efficiency and capacity building. By fostering collaboration and mutual trust, regulatory reliance contributes to equitable and improved patient access to medicines and medical devices.